Antidiabetic effects of extracts from Psidium guajava
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Won Keun Oh | - |
| dc.contributor.author | Chul Ho Lee | - |
| dc.contributor.author | Myung Sun Lee | - |
| dc.contributor.author | Eun Young Bae | - |
| dc.contributor.author | C B Sohn | - |
| dc.contributor.author | Hyuncheol Oh | - |
| dc.contributor.author | Bo Yeon Kim | - |
| dc.contributor.author | Jong Seog Ahn | - |
| dc.date.accessioned | 2017-04-19T09:02:12Z | - |
| dc.date.available | 2017-04-19T09:02:12Z | - |
| dc.date.issued | 2005 | - |
| dc.identifier.issn | 0378-8741 | - |
| dc.identifier.uri | 10.1016/j.jep.2004.09.041 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6798 | - |
| dc.description.abstract | During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Leprdb/Leprdb mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10 mg/kg in both 1- and 3-month-old Leprdb/Leprdb mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Leprdb/Lepr db mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B. | - |
| dc.publisher | Elsevier | - |
| dc.title | Antidiabetic effects of extracts from Psidium guajava | - |
| dc.title.alternative | Antidiabetic effects of extracts from Psidium guajava | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Ethnopharmacology | - |
| dc.citation.number | 3 | - |
| dc.citation.endPage | 415 | - |
| dc.citation.startPage | 411 | - |
| dc.citation.volume | 96 | - |
| dc.contributor.affiliatedAuthor | Won Keun Oh | - |
| dc.contributor.affiliatedAuthor | Chul Ho Lee | - |
| dc.contributor.affiliatedAuthor | Myung Sun Lee | - |
| dc.contributor.affiliatedAuthor | Eun Young Bae | - |
| dc.contributor.affiliatedAuthor | Hyuncheol Oh | - |
| dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
| dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
| dc.contributor.alternativeName | 오원근 | - |
| dc.contributor.alternativeName | 이철호 | - |
| dc.contributor.alternativeName | 이명선 | - |
| dc.contributor.alternativeName | 배은영 | - |
| dc.contributor.alternativeName | 손천배 | - |
| dc.contributor.alternativeName | 오현철 | - |
| dc.contributor.alternativeName | 김보연 | - |
| dc.contributor.alternativeName | 안종석 | - |
| dc.identifier.bibliographicCitation | Journal of Ethnopharmacology, vol. 96, no. 3, pp. 411-415 | - |
| dc.identifier.doi | 10.1016/j.jep.2004.09.041 | - |
| dc.subject.keyword | Blood glucose | - |
| dc.subject.keyword | Leprdb/Leprdb mice | - |
| dc.subject.keyword | Psidium guajava | - |
| dc.subject.keyword | PTP1B | - |
| dc.subject.keyword | Type 2 diabetes | - |
| dc.subject.local | Blood glucose | - |
| dc.subject.local | blood glucose | - |
| dc.subject.local | Leprdb/Leprdb mice | - |
| dc.subject.local | Psidium guajava | - |
| dc.subject.local | PTP1B | - |
| dc.subject.local | PTP 1B | - |
| dc.subject.local | Type 2 diabetes | - |
| dc.subject.local | Type 2 Diabetes | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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