Ultrastructural analysis of chemical synapses in cultured wild type Drosophila embryonic neurons = 초파리 배자 신경세포의 화학적 신경연접 미세구조

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Title
Ultrastructural analysis of chemical synapses in cultured wild type Drosophila embryonic neurons = 초파리 배자 신경세포의 화학적 신경연접 미세구조
Author(s)
Hyun Woo OhHo Yong Park
Bibliographic Citation
Korean Journal of Electron Microscopy, vol. 34, no. 4, pp. 223-230
Publication Year
2004
Abstract
To identify the structural basis of mutations that affect synaptic transmission we have begun quantitative ultrastructural descriptions of synapses in cultured Drosophila embryonic neurons. In wild-type cultures, synapses are distinguished by the parallel arrangement of a thickened pre- and post synaptic membrane separated by a synaptic cleft. The presynaptic active zones and postsynaptic densities are defined by electron dense material close to the membrane. Presynaptic regions are also characterized by the presence of one or more electron dense regions, presynaptic densities, around which a variable number of small, clear core synaptic vesicles (mean nm in diameter) are clustered. Subsets of these vesicles are in direct contact with either the presynaptic density or the membrane and are considered morphologically docked. A small number of larger, dense core vesicles are also observed in most presynaptic profiles.
Keyword
drosophilasynapsevesicle
ISSN
I000-0077
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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