Evolution of microRNAs located within Hox gene clusters

Cited 129 time in scopus
Metadata Downloads
Title
Evolution of microRNAs located within Hox gene clusters
Author(s)
A Tanzer; C T Amemiya; Chang-Bae Kim; P F Stadler
Bibliographic Citation
Journal of Experimental Zoology Part B-Molecular and Developmental Evolution, vol. 304B, no. 1, pp. 75-85
Publication Year
2005
Abstract
MicroRNAs (miRNAs) form an abundant class of non-coding RNA genes that have an important function in post-transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss.
ISSN
1552-5007
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/jez.b.21021
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.