In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

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Title
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia
Author(s)
Y C Kim; Hyuncheol Oh; Beom Seok Kim; T H Kang; E K Ko; Yu Mi Han; Bo Yeon KimJong Seog Ahn
Bibliographic Citation
Planta Medica, vol. 71, no. 1, pp. 87-89
Publication Year
2005
Abstract
Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for B diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2005-837759
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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