Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice

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dc.contributor.authorAi-Guo Wang-
dc.contributor.authorH B Moon-
dc.contributor.authorY H Lee-
dc.contributor.authorSeong Lan Yu-
dc.contributor.authorHyun Jung Kwon-
dc.contributor.authorY H Han-
dc.contributor.authorW Fang-
dc.contributor.authorT H Lee-
dc.contributor.authorK L Jang-
dc.contributor.authorS K Kim-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorDong Seok Lee-
dc.date.accessioned2017-04-19T09:02:30Z-
dc.date.available2017-04-19T09:02:30Z-
dc.date.issued2004-
dc.identifier.issnI0000028-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6848-
dc.description.abstractHepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are cytopathic to liver, three types of transgenic mice were established. The expression of transgenes was confirmed by HCV specific RT-PCR and Western immunoblotting. The livers of all wild type core and S116I transgenic lineages remained largely histologically normal. However, the livers of the S99Q transgenic mice showed significant high level of cell dysplasia associated with the transgene expression in hepatocytes largely located around the central veins by in situ hybridization analysis. In conclusion, the mutant HCV core protein at S99Q may contribute to the progress of HCV induced liver disease.-
dc.publisherSpringer-Nature Pub Group-
dc.titleTransgenic expression of Korean type hepatitis C virus core protein and related mutants in mice-
dc.title.alternativeTransgenic expression of Korean type hepatitis C virus core protein and related mutants in mice-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number6-
dc.citation.endPage593-
dc.citation.startPage588-
dc.citation.volume36-
dc.contributor.alternativeName왕애국-
dc.contributor.alternativeName문형배-
dc.contributor.alternativeName이영호-
dc.contributor.alternativeName유성란-
dc.contributor.alternativeName권현정-
dc.contributor.alternativeNameHan-
dc.contributor.alternativeNameFang-
dc.contributor.alternativeName이태훈-
dc.contributor.alternativeName장경립-
dc.contributor.alternativeName김상근-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName이동석-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 36, no. 6, pp. 588-593-
dc.identifier.doi10.1038/emm.2004.76-
dc.subject.keywordcore-
dc.subject.keyworddysplasia-
dc.subject.keywordhepatitis C virus-
dc.subject.keywordtransgenic mice-
dc.subject.localcore-
dc.subject.localCore-
dc.subject.localdysplasia-
dc.subject.localDysplasia-
dc.subject.localhepatitis C virus-
dc.subject.localHepatitis C virus-
dc.subject.localtransgenic mice-
dc.subject.localtransgenic mouse-
dc.description.journalClassY-
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