DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ai-Guo Wang | - |
dc.contributor.author | H B Moon | - |
dc.contributor.author | Y H Lee | - |
dc.contributor.author | Seong Lan Yu | - |
dc.contributor.author | Hyun Jung Kwon | - |
dc.contributor.author | Y H Han | - |
dc.contributor.author | W Fang | - |
dc.contributor.author | T H Lee | - |
dc.contributor.author | K L Jang | - |
dc.contributor.author | S K Kim | - |
dc.contributor.author | Dae Yeul Yu | - |
dc.contributor.author | Dong Seok Lee | - |
dc.date.accessioned | 2017-04-19T09:02:30Z | - |
dc.date.available | 2017-04-19T09:02:30Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | I000-0028 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6848 | - |
dc.description.abstract | Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are cytopathic to liver, three types of transgenic mice were established. The expression of transgenes was confirmed by HCV specific RT-PCR and Western immunoblotting. The livers of all wild type core and S116I transgenic lineages remained largely histologically normal. However, the livers of the S99Q transgenic mice showed significant high level of cell dysplasia associated with the transgene expression in hepatocytes largely located around the central veins by in situ hybridization analysis. In conclusion, the mutant HCV core protein at S99Q may contribute to the progress of HCV induced liver disease. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice | - |
dc.title.alternative | Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice | - |
dc.type | Article | - |
dc.citation.title | Experimental and Molecular Medicine | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 593 | - |
dc.citation.startPage | 588 | - |
dc.citation.volume | 36 | - |
dc.contributor.affiliatedAuthor | Ai-Guo Wang | - |
dc.contributor.affiliatedAuthor | Seong Lan Yu | - |
dc.contributor.affiliatedAuthor | Hyun Jung Kwon | - |
dc.contributor.affiliatedAuthor | Dae Yeul Yu | - |
dc.contributor.affiliatedAuthor | Dong Seok Lee | - |
dc.contributor.alternativeName | 왕애국 | - |
dc.contributor.alternativeName | 문형배 | - |
dc.contributor.alternativeName | 이영호 | - |
dc.contributor.alternativeName | 유성란 | - |
dc.contributor.alternativeName | 권현정 | - |
dc.contributor.alternativeName | Han | - |
dc.contributor.alternativeName | Fang | - |
dc.contributor.alternativeName | 이태훈 | - |
dc.contributor.alternativeName | 장경립 | - |
dc.contributor.alternativeName | 김상근 | - |
dc.contributor.alternativeName | 유대열 | - |
dc.contributor.alternativeName | 이동석 | - |
dc.identifier.bibliographicCitation | Experimental and Molecular Medicine, vol. 36, no. 6, pp. 588-593 | - |
dc.identifier.doi | 10.1038/emm.2004.76 | - |
dc.subject.keyword | core | - |
dc.subject.keyword | dysplasia | - |
dc.subject.keyword | hepatitis C virus | - |
dc.subject.keyword | transgenic mice | - |
dc.subject.local | core | - |
dc.subject.local | Core | - |
dc.subject.local | dysplasia | - |
dc.subject.local | Dysplasia | - |
dc.subject.local | hepatitis C virus | - |
dc.subject.local | Hepatitis C virus | - |
dc.subject.local | transgenic mice | - |
dc.subject.local | Transgenic mice | - |
dc.subject.local | Transgenic mouse | - |
dc.subject.local | transgenic mouse | - |
dc.description.journalClass | Y | - |
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