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- Title
- Protein kinases as pharmacological targets for the reduction of interleukin-1 expression in lipopolysaccaride-activated primary glial cell
- Author(s)
- H N Sun; W Fang; M H Jin; Y H Han; Sun-Uk Kim; S H Lee; Nam-Soon Kim; Cheol Hee Kim; Dong Seok Lee
- Bibliographic Citation
- Korean Journal of Biomedical Laboratory Science, vol. 10, no. 4, pp. 325-332
- Publication Year
- 2004
- Abstract
- Inflammatory factor such as Interleukin-1 play important roles in determining the fate of both acute and chronic neurological disorders. We investigated whether inhibitors of PKC or PTK can serve as pharmacological agents to reduce IL-1 production and the mechanisms underlying their pharmacological effects in a mixed population of glia. Inhibitors of PKC such as H7, Go6976 and Ro31-8220 significantly reduced both the mRNA and protein levels of IL-1α and IL-β in lipopolysaccharide-activated primary glial cells. While the PTK inhibitor genistein also significantly reduced the production of these cytokines, it did not affect the expression of their mRNA. Taken together, inhibitors of PKC and PTK could serve as pharmacological agents to reduce IL-1 production. However, the mechanisms underlying their pharmacological effects are different. Our results provide evidence that inhibitors of protein kinases can serve as pharmacological agents to modulate IL-1 production in glial cell, and in turn, alleviate neuronal injury.
- Keyword
- glial cellmicrogliainterleukin-1neuroinflammation
- ISSN
- 1226-0487
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
- Files in This Item:
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