VDUP1 is required for the development of natural killer cells

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dc.contributor.authorKee Nyung Lee-
dc.contributor.authorH S Kang-
dc.contributor.authorJun Ho Jeon-
dc.contributor.authorE M Kim-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorHyunKeun Song-
dc.contributor.authorChil Youl Lyu-
dc.contributor.authorZ H Piao-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorY H Han-
dc.contributor.authorS S Song-
dc.contributor.authorY H Lee-
dc.contributor.authorK S Song-
dc.contributor.authorYong Man Kim-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:02:31Z-
dc.date.available2017-04-19T09:02:31Z-
dc.date.issued2005-
dc.identifier.issn1074-7613-
dc.identifier.uri10.1016/j.immuni.2004.12.012ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6853-
dc.description.abstractVitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.-
dc.publisherElsevier-Cell Press-
dc.titleVDUP1 is required for the development of natural killer cells-
dc.title.alternativeVDUP1 is required for the development of natural killer cells-
dc.typeArticle-
dc.citation.titleImmunity-
dc.citation.number2-
dc.citation.endPage208-
dc.citation.startPage195-
dc.citation.volume22-
dc.contributor.affiliatedAuthorKee Nyung Lee-
dc.contributor.affiliatedAuthorJun Ho Jeon-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorHyunKeun Song-
dc.contributor.affiliatedAuthorChil Youl Lyu-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorYong Man Kim-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName이기녕-
dc.contributor.alternativeName강형식-
dc.contributor.alternativeName전준호-
dc.contributor.alternativeName김은미-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName송현근-
dc.contributor.alternativeName유칠열-
dc.contributor.alternativeNamePiao-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeNameHan-
dc.contributor.alternativeName송수성-
dc.contributor.alternativeName이영호-
dc.contributor.alternativeName송규상-
dc.contributor.alternativeName김용만-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationImmunity, vol. 22, no. 2, pp. 195-208-
dc.identifier.doi10.1016/j.immuni.2004.12.012-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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