DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kee Nyung Lee | - |
dc.contributor.author | H S Kang | - |
dc.contributor.author | Jun Ho Jeon | - |
dc.contributor.author | E M Kim | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | HyunKeun Song | - |
dc.contributor.author | Chil Youl Lyu | - |
dc.contributor.author | Z H Piao | - |
dc.contributor.author | Sun-Uk Kim | - |
dc.contributor.author | Y H Han | - |
dc.contributor.author | S S Song | - |
dc.contributor.author | Y H Lee | - |
dc.contributor.author | K S Song | - |
dc.contributor.author | Yong Man Kim | - |
dc.contributor.author | Dae Yeul Yu | - |
dc.contributor.author | In Pyo Choi | - |
dc.date.accessioned | 2017-04-19T09:02:31Z | - |
dc.date.available | 2017-04-19T09:02:31Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | 10.1016/j.immuni.2004.12.012 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6853 | - |
dc.description.abstract | Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo. | - |
dc.publisher | Elsevier-Cell Press | - |
dc.title | VDUP1 is required for the development of natural killer cells | - |
dc.title.alternative | VDUP1 is required for the development of natural killer cells | - |
dc.type | Article | - |
dc.citation.title | Immunity | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 208 | - |
dc.citation.startPage | 195 | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Kee Nyung Lee | - |
dc.contributor.affiliatedAuthor | Jun Ho Jeon | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | HyunKeun Song | - |
dc.contributor.affiliatedAuthor | Chil Youl Lyu | - |
dc.contributor.affiliatedAuthor | Sun-Uk Kim | - |
dc.contributor.affiliatedAuthor | Yong Man Kim | - |
dc.contributor.affiliatedAuthor | Dae Yeul Yu | - |
dc.contributor.affiliatedAuthor | In Pyo Choi | - |
dc.contributor.alternativeName | 이기녕 | - |
dc.contributor.alternativeName | 강형식 | - |
dc.contributor.alternativeName | 전준호 | - |
dc.contributor.alternativeName | 김은미 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 송현근 | - |
dc.contributor.alternativeName | 유칠열 | - |
dc.contributor.alternativeName | Piao | - |
dc.contributor.alternativeName | 김선욱 | - |
dc.contributor.alternativeName | Han | - |
dc.contributor.alternativeName | 송수성 | - |
dc.contributor.alternativeName | 이영호 | - |
dc.contributor.alternativeName | 송규상 | - |
dc.contributor.alternativeName | 김용만 | - |
dc.contributor.alternativeName | 유대열 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.identifier.bibliographicCitation | Immunity, vol. 22, no. 2, pp. 195-208 | - |
dc.identifier.doi | 10.1016/j.immuni.2004.12.012 | - |
dc.description.journalClass | Y | - |
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