Flavonoid compounds from Viola hondoensis and their effect on matrix metalloproteinase-1 in ultraviolet irradiation of cultured human skin fibroblasts

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Title
Flavonoid compounds from Viola hondoensis and their effect on matrix metalloproteinase-1 in ultraviolet irradiation of cultured human skin fibroblasts
Author(s)
H I Moon; Joongku Lee; O P Zee; J H Chung
Bibliographic Citation
Food Science and Biotechnology, vol. 14, no. 1, pp. 143-146
Publication Year
2005
Abstract
Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of 2',4',7-trihydroxyisoflavone on the regulation of MMP-1 and type 1 procollagen in Ultraviolet irradiation of cultured human dermal fibroblasts. Phytochemical investigation of the whole plants of Viola hondoensis led to the isolation of five flavonoids. The structures of these compounds were identified 2',4',5,7-tetrahydroxyisoflavone (1), 2',4',7- trihydroxyisoflavone (2), 4',7-dihydroxyflavone (3), isoorientin (4), and isovitexin (5) using spectroscopic analysis. Among these, 2',4',7-trihydroxyisoflavone reduced the expression of MMP-1 at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that 2',4',7-trihydroxyisoflavone an important role in the reduction of MMP-1 induction by ultraviolet irradiation.
Keyword
viola hondoensismatrix metalloproteinase-1ultraviolet irradiationflavonoid
ISSN
1226-7708
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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