Polyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng

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dc.contributor.authorMun Chual Rho-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorJong Sun Chang-
dc.contributor.authorOh Eok Kwon-
dc.contributor.authorMi Yeon Chung-
dc.contributor.authorYoung Kook Kim-
dc.date.accessioned2017-04-19T09:02:34Z-
dc.date.available2017-04-19T09:02:34Z-
dc.date.issued2005-
dc.identifier.issn00218561-
dc.identifier.uri10.1021/jf040370xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6875-
dc.description.abstractAcyl-CoA: cholesterol acyltransferase (ACAT), which plays a role in the absorption, storage, and production of cholesterol, has been explored as a potential target for pharmacological intervention of hyperlipidemia and atherosclerotic disease. In our search for ACAT inhibitors from natural sources, the petroleum ether extract of Panax ginseng showed moderate inhibition of ACAT enzyme from rat liver microsomes. Bioactivity-guided fractionations led to the isolation of one new polyacetylenic compound, (9R,10S)-epoxy-16-heptadecene-4, 6-diyne-3-one (1), in addition to the previously reported polyacetylenic compounds 2 and 3. Their chemical structures were elucidated on the basis of spectroscopic evidence (UV, IR, NMR, and MS). The compounds 1, 2, and 3 showed significant ACAT inhibition with IC50 values of 35, 47, and 21 μM, respectively.-
dc.publisherAmer Chem Soc-
dc.titlePolyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng-
dc.title.alternativePolyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng-
dc.typeArticle-
dc.citation.titleJournal of Agricultural and Food Chemistry-
dc.citation.number4-
dc.citation.endPage922-
dc.citation.startPage919-
dc.citation.volume53-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName장종선-
dc.contributor.alternativeName권오억-
dc.contributor.alternativeName정미연-
dc.contributor.alternativeName김영국-
dc.identifier.bibliographicCitationJournal of Agricultural and Food Chemistry, vol. 53, no. 4, pp. 919-922-
dc.identifier.doi10.1021/jf040370x-
dc.subject.keywordAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordCholesteryl ester-
dc.subject.keywordPanax ginseng-
dc.subject.keywordPolyacetylenes-
dc.subject.localAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localAtherosclerosis-
dc.subject.localCholesteryl ester-
dc.subject.localPanax ginseng-
dc.subject.localPolyacetylenes-
dc.subject.localPolyacetylene-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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