Multifunctional drug delivery system using starch-alginate beads for controlled release

Cited 34 time in scopus
Metadata Downloads
Title
Multifunctional drug delivery system using starch-alginate beads for controlled release
Author(s)
Young Joo Kim; H G Park; Young Lyul Yang; Y Yoon; Sang Soo Kim; E Oh
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 28, no. 2, pp. 394-397
Publication Year
2005
Abstract
Utilizing starch-containing alginate beads, a novel drug delivery system (DDS) was developed. With the starch inside, the composite bead could be dried in its original bead shape and handled in the dried state. By employing alginate multi-coating strategy on the starch-alginate beads, detained or controlled release was efficiently achieved and successfully demonstrated for a model peptide drug, L-phenylalanine. The initial latent time and release rate of the drug inside the beads were able to be controlled simply by varying the number of multi-coatings. While the latent time for the initial release was negligible for non-coated starch-alginate beads, the latent times of beads coated one, two, and four times increased to 15, 30, and 70 min, respectively. Furthermore, the alginate component of the composite beads could adsorb and remove heavy metals such as lead from the body. These multifunctional beads combined with the novel coating process will greatly benefit alginate gel-based DDS.
Keyword
Alginate beadCoatingControlled releaseDrug delivery systemStarch
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.28.394
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.