Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis

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dc.contributor.authorSeung Woong Lee-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorJung Yeon Nam-
dc.contributor.authorOh Eok Kwon-
dc.contributor.authorJin Ah Baek-
dc.contributor.authorJong Sun Chang-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorYoung Kook Kim-
dc.date.accessioned2017-04-19T09:02:39Z-
dc.date.available2017-04-19T09:02:39Z-
dc.date.issued2005-
dc.identifier.issn0378-8741-
dc.identifier.uri10.1016/j.jep.2004.12.006ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6901-
dc.description.abstractThe accumulation of circulating monocytes in the arterial wall is an early in atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) promotes the migration of monocytes and would play a role in the development of atherosclerotic lesions. Searching for inhibitors of MCP-1-induced cell migration from natural sources, we isolated one active compound through active-guided fractionations from the MeOH extracts of Sophora flavescens Ait (Leguminosae). On the basis of spectral evidence, the structure of active compound was identified as kurarinone. It inhibited the migration of THP-1 cells induced by MCP-1 with IC50 value of 19.2 μg/mL. In addition, it inhibited the binding of MCP-1 to THP-1 cells and phosphorylation of p42/44 MARK.-
dc.publisherElsevier-
dc.titleKurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis-
dc.title.alternativeKurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis-
dc.typeArticle-
dc.citation.titleJournal of Ethnopharmacology-
dc.citation.number3-
dc.citation.endPage519-
dc.citation.startPage515-
dc.citation.volume97-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorJung Yeon Nam-
dc.contributor.affiliatedAuthorOh Eok Kwon-
dc.contributor.affiliatedAuthorJin Ah Baek-
dc.contributor.affiliatedAuthorJong Sun Chang-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorYoung Kook Kim-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName남정연-
dc.contributor.alternativeName권오억-
dc.contributor.alternativeName백진아-
dc.contributor.alternativeName장종선-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName김영국-
dc.identifier.bibliographicCitationJournal of Ethnopharmacology, vol. 97, no. 3, pp. 515-519-
dc.identifier.doi10.1016/j.jep.2004.12.006-
dc.subject.keywordActive-guided fractionations-
dc.subject.keywordCC chemokine receptor 2-
dc.subject.keywordKurarinone-
dc.subject.keywordMonocyte chemoattractant protein-1-
dc.subject.keywordSophora flavescens Ait-
dc.subject.localActive-guided fractionations-
dc.subject.localCC chemokine receptor 2-
dc.subject.localKurarinone-
dc.subject.localMonocyte chemoattractant protein-1-
dc.subject.localmonocyte chemoattractant protein-1-
dc.subject.localSophora flavescens Ait-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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