Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens

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Title
Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens
Author(s)
Kwang Hee Son; Hyun Mi Oh; Sung Kyu Choi; Dong Cho HanByoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 8, pp. 2019-2021
Publication Year
2005
Abstract
A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6α-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI 50 2-5 μg/mL.
Keyword
Abietane diterpeneAnti-tumorCancer cell
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2005.02.057
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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