Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens
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- Title
- Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens
- Author(s)
- Kwang Hee Son; Hyun Mi Oh; Sung Kyu Choi; Dong Cho Han; Byoung-Mog Kwon
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 8, pp. 2019-2021
- Publication Year
- 2005
- Abstract
- A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6α-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI 50 2-5 μg/mL.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmcl.2005.02.057
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Division of A.I. & Biomedical Research > Genomic Medicine Research Center > 1. Journal Articles
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