Inhibitory effect of jaceosidin isolated from Artemisia argyi on the function of E6 and E7 oncoproteins of HPV 16

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Title
Inhibitory effect of jaceosidin isolated from Artemisia argyi on the function of E6 and E7 oncoproteins of HPV 16
Author(s)
Hee Gu Lee; Kyung Ae Yu; Won Keun Oh; Tae Woong Baeg; H C Oh; Jong Seog Ahn; W C Jang; Jong Wan Kim; J S Lim; Yong Kyung Choe; Do Young Yoon
Bibliographic Citation
Journal of Ethnopharmacology, vol. 98, no. 3, pp. 339-343
Publication Year
2005
Abstract
Jaceosidin (4′,5,7-trihydroxy-3′,6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor. Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein. In addition, jaceosidin inhibited binding between the E7 oncoprotein and the Rb tumor suppressor protein, and also inhibited the function of HPV-16 harboring cervical cancer cells, including SiHa and CaSki. Collectively, jaceosidin inhibited the functions of the E6 and E7 oncoproteins of the human papillomavirus, suggesting that this compound might be used as a potential drug for the treatment of cervical cancers associated with the human papillomavirus.
Keyword
Artermisia argyiCervical cancerE6E7HPVJaceosidin
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jep.2005.01.054
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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