Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1

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Title
Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1
Author(s)
Ai Guo Wang; S B Seo; H B Moon; H J SHin; D H Kim; J M Kim; T H Lee; H J Kwon; Dae Yeul Yu; Dong Seok Lee
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 330, no. 2, pp. 461-466
Publication Year
2005
Abstract
It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.
Keyword
Histone deacetylase 1Nuclear pleomorphismp21p53Steatosis
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2005.02.179
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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