Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes

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Title
Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes
Author(s)
J Y Lee; S S Moon; Bong Sik Yun; Ick Dong Yoo; B K Hwang
Bibliographic Citation
Journal of Natural Products, vol. 67, no. 12, pp. 2076-2078
Publication Year
2004
Abstract
A novel butanoic acid, thiobutacin (1), 4-(2-aminophenyl)-4-oxo-2- methylthiobutanoic acid (C11H13NO3S), was isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9. The structure of thiobutacin (1) was elucidated on the basis of the extensive 2D NMR spectral data including 1H- 1H COSY, HMBC, HMQC, ROESY, and NOESY. Thiobutacin (1) showed antioomycete and antifungal activity against phytopathogenic Phytophthora capsici and Botrytis cinerea and the yeast Saccharomyces cerevisiae.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np049786v
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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