식용식물자원으로부터 활성물질의 탐색-XII: 꽃마리(Trigonotis peduncularis Benth.)로부터 Flavonol 배당체의 분리 및 hACAT1 저해활성

Cited 0 time in scopus
Metadata Downloads
Title
식용식물자원으로부터 활성물질의 탐색-XII: 꽃마리(Trigonotis peduncularis Benth.)로부터 Flavonol 배당체의 분리 및 hACAT1 저해활성
Author(s)
H J Yang; M C Song; M H Bang; J H Lee; I S Chung; Y H Lee; Tae Sook Jeong; Byoung-Mog Kwon; S H Kim; D K Kim; M H Park; N I Baek
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 48, no. 1, pp. 98-102
Publication Year
2005
Abstract
The MeOH extracts obtained from whole plant of Trigonotis peduncularis Benth. were solvent fractionated using EtOAc, n-BuOH and water, successively. The EtOAc and n-BuOH fractions gave four flavonol glycosides through application of silica gel and octadecyl silica gel (ODS) column chromatographies. The chemical structures of the flavonol glycosides were determined by the interpretation of several spectral data including 2D-NMR as kaempferol-3-O-β-D-glucopyranoside (astragalin, 1), kaempferol-3-O-α-L-rhamnopyranosyl (1?6)-β-D-glucopyranoside (nicotiflorin, 2), quercetin-3-O-α-L-rhamnopyranosyl(1?6)-β-D-glucopyranoside (rutin, 3), quercetin-3-O-β-D-glucopyranoside (isoquercitrin, 4). The flavonoids have been first isolated from this plant. Nicotiflorin (100 μg/ml) showed 68.3?1.2% of the inhibitory effect on hACAT1(human Acyl CoA: cholesterol transferase 1) activity.
Keyword
trigonotis peduncularisflavonol glycosideastragalinnicotiflorinrutinisoquercitrinhACAT1
ISSN
I000-0171
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.