The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

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dc.contributor.authorY Yang-
dc.contributor.authorJeong-Hyung Lee-
dc.contributor.authorKun Yong Kim-
dc.contributor.authorH K Song-
dc.contributor.authorJae Kwang Kim-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorD Cho-
dc.contributor.authorK S Song-
dc.contributor.authorY H Lee-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:02:44Z-
dc.date.available2017-04-19T09:02:44Z-
dc.date.issued2005-
dc.identifier.issn03043835-
dc.identifier.uri10.1016/j.canlet.2004.08.022ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6929-
dc.description.abstractAs an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.-
dc.publisherElsevier-
dc.titleThe interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells-
dc.title.alternativeThe interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells-
dc.typeArticle-
dc.citation.titleCancer Letters-
dc.citation.number2-
dc.citation.endPage200-
dc.citation.startPage191-
dc.citation.volume221-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName양영-
dc.contributor.alternativeName이정형-
dc.contributor.alternativeName김근영-
dc.contributor.alternativeName송현근-
dc.contributor.alternativeName김재광-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName조대호-
dc.contributor.alternativeName송규상-
dc.contributor.alternativeName이영호-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationCancer Letters, vol. 221, no. 2, pp. 191-200-
dc.identifier.doi10.1016/j.canlet.2004.08.022-
dc.subject.keyword9-27-
dc.subject.keywordIFN-γ-
dc.subject.keywordinvasion-
dc.subject.keywordnatural killer cell-
dc.subject.local9-27-
dc.subject.localIFN-γ-
dc.subject.localinvasion-
dc.subject.localInvasion-
dc.subject.localnatural killer cell-
dc.subject.localNatural killer cell-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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