Identification and antibacterial activity of a new oleandomycin derivative from streptomyces antibioticus

Cited 1 time in scopus
Metadata Downloads
Title
Identification and antibacterial activity of a new oleandomycin derivative from streptomyces antibioticus
Author(s)
Beom Seok Kim; H Oh; Sun Young Kim; Jeong Ah Park; Y J Yoon; S K Lee; Bo Yeon KimJong Seog Ahn
Bibliographic Citation
Journal of Antibiotics, vol. 58, no. 3, pp. 196-201
Publication Year
2005
Abstract
During the study on the oleandomycin production, we purified a new oleandomycin derivative having a macrolactone of which biosynthesis does not follow the genetic architecture of the oleandomycin PKS. The molecular formula for the compound was suggested as C35H59NO11 on the basis of the analysis of NMR and HRMS data (m/z 670.4185, Δ-1.9 mmu, calcd for C35H60NO11). 13C NMR assignments and analysis of COSY, HMBC and HMQC data suggested that the compound differs from oleandomycin by formation of the olefinic functionality resulting from the dehydration of a hydroxy group in oleandomycin. The new oleandomycin derivative has antibacterial activities similar to those of oleandomycin agaisnt Enterococcus faecalis, Bacillus subtilis and Staphylococcus aureus.
Keyword
dehydration of hydroxyl groupnew oleandomycin derivativeolefinic formationstreptomyces antibioticus
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2005.23
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.