Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Soo Jin Choo | - |
| dc.contributor.author | H R Park | - |
| dc.contributor.author | In Ja Ryoo | - |
| dc.contributor.author | Jong Pyung Kim | - |
| dc.contributor.author | Bong Sik Yun | - |
| dc.contributor.author | Chang-Jin Kim | - |
| dc.contributor.author | K Shin-ya | - |
| dc.contributor.author | Ick Dong Yoo | - |
| dc.date.accessioned | 2017-04-19T09:02:46Z | - |
| dc.date.available | 2017-04-19T09:02:46Z | - |
| dc.date.issued | 2005 | - |
| dc.identifier.issn | 0021-8820 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6938 | - |
| dc.description.abstract | Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC 50 of 30 nM. | - |
| dc.publisher | Springer-Nature Pub Group | - |
| dc.title | Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp. | - |
| dc.title.alternative | Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp. | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Antibiotics | - |
| dc.citation.number | 3 | - |
| dc.citation.endPage | 213 | - |
| dc.citation.startPage | 210 | - |
| dc.citation.volume | 58 | - |
| dc.contributor.affiliatedAuthor | Soo Jin Choo | - |
| dc.contributor.affiliatedAuthor | In Ja Ryoo | - |
| dc.contributor.affiliatedAuthor | Jong Pyung Kim | - |
| dc.contributor.affiliatedAuthor | Bong Sik Yun | - |
| dc.contributor.affiliatedAuthor | Chang-Jin Kim | - |
| dc.contributor.affiliatedAuthor | Ick Dong Yoo | - |
| dc.contributor.alternativeName | 추수진 | - |
| dc.contributor.alternativeName | 박해룡 | - |
| dc.contributor.alternativeName | 류인자 | - |
| dc.contributor.alternativeName | 김종평 | - |
| dc.contributor.alternativeName | 윤봉식 | - |
| dc.contributor.alternativeName | 김창진 | - |
| dc.contributor.alternativeName | Shin-ya | - |
| dc.contributor.alternativeName | 유익동 | - |
| dc.identifier.bibliographicCitation | Journal of Antibiotics, vol. 58, no. 3, pp. 210-213 | - |
| dc.identifier.doi | 10.1038/ja.2005.26 | - |
| dc.subject.keyword | Anticancer agents | - |
| dc.subject.keyword | Deoxyverrucosidin | - |
| dc.subject.keyword | Glucose-regulated protein 78 (GRP78) | - |
| dc.subject.keyword | Penicillium sp. | - |
| dc.subject.local | Anticancer Agents | - |
| dc.subject.local | Anti-cancer agents | - |
| dc.subject.local | anti-cancer agent | - |
| dc.subject.local | Anti-cancer agent | - |
| dc.subject.local | Anticancer agent | - |
| dc.subject.local | Anticancer agents | - |
| dc.subject.local | Anticancer Agent | - |
| dc.subject.local | anticancer agent | - |
| dc.subject.local | Deoxyverrucosidin | - |
| dc.subject.local | Glucose-regulated protein 78 (GRP78) | - |
| dc.subject.local | penicillium sp. | - |
| dc.subject.local | Penicillium sp. | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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