Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.

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dc.contributor.authorSoo Jin Choo-
dc.contributor.authorH R Park-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorJong Pyung Kim-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorChang-Jin Kim-
dc.contributor.authorK Shin-ya-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T09:02:46Z-
dc.date.available2017-04-19T09:02:46Z-
dc.date.issued2005-
dc.identifier.issn0021-8820-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6938-
dc.description.abstractGlucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC 50 of 30 nM.-
dc.publisherSpringer-Nature Pub Group-
dc.titleDeoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.-
dc.title.alternativeDeoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.-
dc.typeArticle-
dc.citation.titleJournal of Antibiotics-
dc.citation.number3-
dc.citation.endPage213-
dc.citation.startPage210-
dc.citation.volume58-
dc.contributor.affiliatedAuthorSoo Jin Choo-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorJong Pyung Kim-
dc.contributor.affiliatedAuthorBong Sik Yun-
dc.contributor.affiliatedAuthorChang-Jin Kim-
dc.contributor.affiliatedAuthorIck Dong Yoo-
dc.contributor.alternativeName추수진-
dc.contributor.alternativeName박해룡-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName김종평-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName김창진-
dc.contributor.alternativeNameShin-ya-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Antibiotics, vol. 58, no. 3, pp. 210-213-
dc.identifier.doi10.1038/ja.2005.26-
dc.subject.keywordAnticancer agents-
dc.subject.keywordDeoxyverrucosidin-
dc.subject.keywordGlucose-regulated protein 78 (GRP78)-
dc.subject.keywordPenicillium sp.-
dc.subject.localAnticancer Agents-
dc.subject.localAnti-cancer agents-
dc.subject.localanti-cancer agent-
dc.subject.localAnti-cancer agent-
dc.subject.localAnticancer agent-
dc.subject.localAnticancer agents-
dc.subject.localAnticancer Agent-
dc.subject.localanticancer agent-
dc.subject.localDeoxyverrucosidin-
dc.subject.localGlucose-regulated protein 78 (GRP78)-
dc.subject.localpenicillium sp.-
dc.subject.localPenicillium sp.-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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