Antioxidant effects of diarylheptanoid derivatives from Alnus japonica on human LDL oxidation

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Title
Antioxidant effects of diarylheptanoid derivatives from Alnus japonica on human LDL oxidation
Author(s)
Woo Song Lee; Ju Ryoung Kim; Kyung Ran Im; Kyung Hyun Cho; D E Sok; Tae Sook Jeong
Bibliographic Citation
Planta Medica, vol. 71, no. 4, pp. 295-299
Publication Year
2005
Abstract
Two diarylheptanoids, oregonin (1) and hirsutanone (2), were isolated by bioassay-guided fractionation of the methanol extracts of the leaves of Alnus japonica Steud and their structures were elucidated from their spectroscopic data. Compounds 1 and 2 exhibited significant low-density lipoprotein (LDL)-antioxidant activities, e.g., thiobarbituric acid-reactive substances (TBARS) assay (1: IC50 = 3.2 μM, 2: IC50 = 1.5 μM), lag time (1:162 min, 2:230 min at 2.0 μM, control: 63 min), relative electrophoretic mobility (REM, inhibition of 1:71%, 2:75% at 10 μM), apoB-100 fragmentation (inhibition of 1:27.3%, 2:40.3% at 10 μM) and macrophage-mediated LDL oxidation (inhibition of 1:82%, 2:84% at 1 μM).
Keyword
Alnus japonicaBetulaceaeHirsutanoneLow-density lipoprotein (LDL)Oregonin
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2005-864093
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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