Isolation of sangivamycin from Streptomyces sp. A6497 and its herbicidal activity

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Isolation of sangivamycin from Streptomyces sp. A6497 and its herbicidal activity
E I Hwang; Bong Sik Yun; S W Choi; J S Kim; S J Lim; Jae Sun Moon; S H Lee; Sung Uk Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 15, no. 2, pp. 434-437
Publication Year
During the screening for the inhibitors of cellulose biosynthesis as herbicides, we discovered a Streptomyces sp. A6497 with a selective antifungal activity against cellulose containing Phytophthora parasitica, but not against cellulose lacking Candida albicans. The inhibitor was isolated and identified, using a series of chromatographies. Based on structure analyses with UV spectrophotometry, mass and various NMR, the inhibitor was identified as sangivamycin. The compound exhibited strong antifungal activities against P. parasitica (MIC; 3.125 μg/ml). In particular, it showed strong herbicidal activities against various weeds in the greenhouse experiment. Taken together, these results suggest that sangivamycin is a useful lead compound for the development of new herbicides.
chemotaxonomyherbicidal activitysangivamycinselective screening
Korea Soc-Assoc-Inst
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Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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