Structures and biological activities of novel antibiotic peptaibols neoatroviridins A - D from Trichoderma atroviride F80317

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Title
Structures and biological activities of novel antibiotic peptaibols neoatroviridins A - D from Trichoderma atroviride F80317
Author(s)
Seung Uk Oh; Bong Sik Yun; S J Lee; Ick Dong Yoo
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 15, no. 2, pp. 384-387
Publication Year
2005
Abstract
Four new antibiotic peptaibols, named neoatroviridins A (1), B (2), C (3), and D (4), have been isolated from the culture broth of Trichoderma atroviride. Their amino acid sequences were determined mainly by mass spectrometry in combination with NMR studies. The absolute stereochemistry of neoatroviridins was established as L by GC analysis of their acid hydrolysates with derivatization, except for isovaline which was in D. Neoatroviridins, composed of 18 amino acid residues, showed significant membrane-perturbing activity responsible for their antibiotic action, which was comparable to that of alamethicin, a well-known 20-residue peptaibol.
Keyword
membrane-perturbing activityneoatroviridinspeptaibol antibioticstructure determinationtrichoderma atroviride
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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