A novel function of benzyl isothiocyanate in vascular smooth muscle cells: The role of ERK1/2, cell cycle regulation, and matrix metalloproteinase-9

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dc.contributor.authorJ Y Lee-
dc.contributor.authorS K Moon-
dc.contributor.authorC W Hwang-
dc.contributor.authorK S Nam-
dc.contributor.authorY K Kim-
dc.contributor.authorH D Yoon-
dc.contributor.authorMin-Gon Kim-
dc.contributor.authorC H Kim-
dc.date.accessioned2017-04-19T09:02:53Z-
dc.date.available2017-04-19T09:02:53Z-
dc.date.issued2005-
dc.identifier.issn0021-9541-
dc.identifier.uri10.1002/jcp.20257ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6967-
dc.description.abstractDietary isothiocyanates (ITCs) have shown protective effects against certain chemically induced cancers in animal models. These inhibitory effects are associated with reduced levels of extracellular signal-regulated kinase (ERK) 1/2 activity and the arrest of the G1 cell cycle. Benzyl isothiocyanate (BITC) treatment down-regulates cyclins and CDKs and up-regulates the expression of the CDK inhibitor p21, but up-regulation of p27 or p53 was not detected. Since antiatherogenic effects are not needed for antiproliferation, we determined whether BITC exerted inhibitory effects on matrix metalloproteinase-9(MMP-9) activity in TNF-α-induced vascular smooth muscle cells (VSMCs). BITC inhibited TNF-α-induced MMP-9 secretion in VSMC in a dose dependent manner. This inhibition was characterized by the down-regulation of MMP-9, which is transcriptionally regulated at the NF-κB site, and the activation protein-1 (AP-1) site in the MMP-9 promoter. These findings indicate that BITC is an effective agent for inhibiting cell proliferation, the G1 to S phase cell cycle progress, and MMP-9 expression through the transcription factors NF-κB and AP-1 in TNF-α-induced VSMC.-
dc.publisherWiley-
dc.titleA novel function of benzyl isothiocyanate in vascular smooth muscle cells: The role of ERK1/2, cell cycle regulation, and matrix metalloproteinase-9-
dc.title.alternativeA novel function of benzyl isothiocyanate in vascular smooth muscle cells: The role of ERK1/2, cell cycle regulation, and matrix metalloproteinase-9-
dc.typeArticle-
dc.citation.titleJournal of Cellular Physiology-
dc.citation.number3-
dc.citation.endPage500-
dc.citation.startPage493-
dc.citation.volume203-
dc.contributor.affiliatedAuthorMin-Gon Kim-
dc.contributor.alternativeName이진영-
dc.contributor.alternativeName문성권-
dc.contributor.alternativeName황철원-
dc.contributor.alternativeName남경수-
dc.contributor.alternativeName김연계-
dc.contributor.alternativeName윤호동-
dc.contributor.alternativeName김민곤-
dc.contributor.alternativeName김철호-
dc.identifier.bibliographicCitationJournal of Cellular Physiology, vol. 203, no. 3, pp. 493-500-
dc.identifier.doi10.1002/jcp.20257-
dc.description.journalClassY-
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