Recent progress in transgenic mouse models as an alternative carcinogenicity bioassay = 형질전환 마우스 모델 발암성 평가의 최신 지견

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dc.contributor.authorW C Son-
dc.contributor.authorB H Kim-
dc.contributor.authorD D Jang-
dc.contributor.authorC K Kim-
dc.contributor.authorB S Han-
dc.contributor.authorJ C Kim-
dc.contributor.authorB H Kang-
dc.contributor.authorJ B Lee-
dc.contributor.authorYang Kyu Choi-
dc.contributor.authorHyoung-Chin Kim-
dc.date.accessioned2017-04-19T09:02:55Z-
dc.date.available2017-04-19T09:02:55Z-
dc.date.issued2005-
dc.identifier.issnI0000084-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6981-
dc.description.abstractTransgenic mouse models have been introduced and accepted by regulatory bodies as an alternative to carcinogenicity assay models to predict and evaluate chemical carcinogens. The recent research outcomes in transgenic mouse models have made progressive advances in the understanding of chemical carcinogenesis and the evaluation of potential human carcinogens. However, these models still remain to be insufficient assay systems although the insufficiencies have been recognised and are being resolved. Based on up to date information from literature, this review article intends to understand currently accepted transgenic mouse models, issues arising from study design, interpretation of the study, results of validation project and their cancer prediction rate, and further perspectives of cancer assay models from the regulatory view point.-
dc.publisherSouth Korea-
dc.titleRecent progress in transgenic mouse models as an alternative carcinogenicity bioassay = 형질전환 마우스 모델 발암성 평가의 최신 지견-
dc.title.alternativeRecent progress in transgenic mouse models as an alternative carcinogenicity bioassay-
dc.typeArticle-
dc.citation.titleJournal of Toxicology and Pubic Health-
dc.citation.number1-
dc.citation.endPage14-
dc.citation.startPage1-
dc.citation.volume21-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.alternativeName손우찬-
dc.contributor.alternativeName김배환-
dc.contributor.alternativeName장동덕-
dc.contributor.alternativeName김철규-
dc.contributor.alternativeName한범석-
dc.contributor.alternativeName김종춘-
dc.contributor.alternativeName강부현-
dc.contributor.alternativeName이제봉-
dc.contributor.alternativeName최양규-
dc.contributor.alternativeName김형진-
dc.identifier.bibliographicCitationJournal of Toxicology and Pubic Health, vol. 21, no. 1, pp. 1-14-
dc.subject.keywordtransgenic mouse-
dc.subject.keywordalternative cancer bioassay-
dc.subject.keywordTg.rasH2-
dc.subject.keywordTg.AC-
dc.subject.keywordXPA+/--
dc.subject.keywordp53+/-
dc.subject.localtransgenic mouse-
dc.subject.localTransgenic mouse-
dc.subject.localalternative cancer bioassay-
dc.subject.localTg.rasH2-
dc.subject.localTg.AC-
dc.subject.localXPA+/--
dc.subject.localp53+/-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
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