Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent

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dc.contributor.authorD H Kim-
dc.contributor.authorS J Jung-
dc.contributor.authorI S Chung-
dc.contributor.authorY H Lee-
dc.contributor.authorD K Kim-
dc.contributor.authorS H Kim-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorM H Park-
dc.contributor.authorN S Seoung-
dc.contributor.authorN I Baek-
dc.date.accessioned2017-04-19T09:02:58Z-
dc.date.available2017-04-19T09:02:58Z-
dc.date.issued2005-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6991-
dc.description.abstractFlowers of Erigeron annuus L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H2O. Repeated silica gel and ODS column chromatography of the EtOAc fraction led to the isolation of a sterol, through activityguided fractionation, using ACAT inhibitory activity measurements. From the physico-chemical data, including NMR, MS, and IR, the chemical structure of the compound was determined to be an ergosterol peroxide (1), which has been isolated for the first time from this plant. This compound exhibited hACAT-1 and Lp-PLA2 inhibitory effects, with inhibitory values of 51.6 ± 0.9 and 51.7 ± 1.2%, at a treatment concentration of 0.23 mM.-
dc.publisherPharmaceutical Soc Korea-
dc.titleErgosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent-
dc.title.alternativeErgosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number5-
dc.citation.endPage545-
dc.citation.startPage541-
dc.citation.volume28-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName김동현-
dc.contributor.alternativeName정성제-
dc.contributor.alternativeName정인식-
dc.contributor.alternativeName이윤형-
dc.contributor.alternativeName김대근-
dc.contributor.alternativeName김성훈-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName박미현-
dc.contributor.alternativeName성낙술-
dc.contributor.alternativeName백남인-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 28, no. 5, pp. 541-545-
dc.identifier.doi10.1007/BF02977755-
dc.subject.keywordCompositae-
dc.subject.keywordErgosterol peroxide-
dc.subject.keywordErigeron annuus L.-
dc.subject.keywordhaCAT1 inhibitory effect-
dc.subject.localCompositae-
dc.subject.localcompositae-
dc.subject.localErgosterol peroxide-
dc.subject.localergosterol peroxide-
dc.subject.localErigeron annuus L.-
dc.subject.localhaCAT1 inhibitory effect-
dc.subject.localhACAT1 inhibitory effect-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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