Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots

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Title
Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots
Author(s)
Woo Song Lee; M J Kim; Y I Beck; Y D Park; Tae Sook Jeong
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 15, pp. 3573-3575
Publication Year
2005
Abstract
(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA 2. The (R)-4 and (S)-4 exhibited Lp-PLA2 inhibitory activities with IC50 values of 45.0 and 52.0 μM, respectively.
Keyword
Saururus chinensisFatty acid glycerolsLp-PLA2 inhibitor
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2005.05.056
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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