Gentisyl alcohol inhibits apoptosis by suppressing caspase activity induced by etoposide

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Title
Gentisyl alcohol inhibits apoptosis by suppressing caspase activity induced by etoposide
Author(s)
JinHee Kim; DongHyun Kim; M Kim; H Kwon; Tae Kwang Oh; Choong Hwan Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 15, no. 3, pp. 532-536
Publication Year
2005
Abstract
In the course of our screening for small molecules to inhibit apoptosis of U937 human leukemia cells induced by etoposide (10 μg/ml), Penicillium sp. F020150 with potent inhibitory activity was selected. The active compound was purified from ethyl acetate extract of the microorganism by Sephadex LH-20 column chromatography and HPLC, and was identified as gentisyl alcohol (2,5-dihydroxybenzyl alcohol) by spectroscopic methods. The compound inhibited caspase-3 induction with IC50 value of 3.0 μg/ml after 8 h of etoposide treatment. The expression levels of caspase-3 and PARP were dose-dependently inhibited by the compound, suggesting that gentisyl alcohol inhibits etoposide-induced apoptosis via downregulation of caspases.
Keyword
apoptosisgentisyl alcoholU937 cells
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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