Flavonoids from the leaves of Litsea japonica and their anti-complement activity

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Title
Flavonoids from the leaves of Litsea japonica and their anti-complement activity
Author(s)
Sun Young Lee; Byung Sun Min; Jung Hee Kim; Joongku Lee; T J Kim; C S Kim; Y H Kim; Hyeong Kyu Lee
Bibliographic Citation
Phytotherapy Research, vol. 19, no. 4, pp. 273-276
Publication Year
2005
Abstract
Four flavonoids, epicatechin (1), afzelin (2), quercitrin (3), and tiliroside (4), were isolated from the leaves of Litsea japonica (Thunb.) Jussieu (Lauraceae). The structures of compounds were identified by comparing their chemical and spectral data with those previously reported. The flavonoids (1-4) were tested for their anti-complement activity against classical pathway of complement system. Compounds 2-4 showed inhibitory activity against complement system with IC50 values of 258, 440, and 101 μM, respectively, whereas 1 was inactive. For the evaluation of the structure-activity relationship of 5,7-dihydroxyflavones, myricitrin (5) from Juglans mandshurica also tested for it's anti-complement activity and is inactive in this assay system. Furthermore, compounds 2,3, and 5 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (5a), and these were also tested for their activity. of the three aglycones, 2a exhibited anticomplement activity with an IC50 value of 730 μM, while 3a and 5a were inactive. The inhibitory potencies of 2, 2a, 3, 3a, 5, and 5a against complement activity increased in inverse proportion to number of free hydroxyls on B-ring of 5,7-dihydroxyflavone. of the compounds tested, 4 showed the most potent inhibitory activity against the complement system.
Keyword
AfzelinAnti-complement activityLitsea japonicaQuercetinTiliroside
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.1453
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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