Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence

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Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence
Ying Hao Han; Hyun Sun Kim; J M Kim; S K Kim; Dae Yeul Yu; Eun Yi Moon
Bibliographic Citation
FEBS Letters, vol. 579, no. 21, pp. 4897-4902
Publication Year
Reactive oxygen species (ROS) were generated in all oxygen-utilizing organisms. Peroxiredoxin II (Prx II) as one of antioxidant enzymes may play a protective role against the oxidative damage caused by ROS. In order to define the role of Prx II in organismal aging, we evaluated cellular senescence in Prx II-/- mouse embryonic fibroblast (MEF). As compared to wild type MEF, cellular senescence was accelerated in Prx II-/- MEF. Senescence-associated (SA)-β-galactosidase (Gal)-positive cell formation was about 30% higher in Prx II-/- MEF. N-Acetyl-l-cysteine (NAC) treatment attenuated SA-β-Gal-positive cell formation. Prx II-/- MEF exhibited the higher G2/M (41%) and lower S (1.6%) phase cells as compared to 24% and 7.4% in wild type MEF, respectively. A high increase in the p16 and a slight increase in the p21 and p53 levels were detected in PrxII-/- MEF cells. The cellular senescence of Prx II-/- MEF was correlated with the organismal aging of Prx II-/- mouse skin. While extracellular signal-regulated kinase (ERK) and p38 activation was detected in Prx II-/- MEF, ERK and c-Jun N-terminal kinase (JNK) activation was detected in Prx II-/- skin. These results suggest that Prx II may function as an enzymatic antioxidant to prevent cellular senescence and skin aging.
AgingCellular senescenceReactive oxygen speciesPeroxiredoxin II
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