Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos = Asparagus oligoclonos의 뿌리로부터 분리한 세포독성활성을 나타내는 스테로이드사포닌

Abstract

Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5β-spirostan-3β,17α-diol 3-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranoside and (25S*)-5β-spirostan-3β,17α-diol 3-O-α-L- rhamnopyanosyl (1→4)-[β-D-xylopyranosyl-(1→2)]-β-D- glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 μg/mL.