Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792

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dc.contributor.authorE I Hwang-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorW H Yeo-
dc.contributor.authorS H Lee-
dc.contributor.authorJae Sun Moon-
dc.contributor.authorYoung Kook Kim-
dc.contributor.authorS J Lim-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T09:03:16Z-
dc.date.available2017-04-19T09:03:16Z-
dc.date.issued2005-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7059-
dc.description.abstractIn the course of screening for selective growth inhibitors against the mycelial form of Candida albicans, we isolated a Streptomyces sp. A6792 from soils. The inhibitor was isolated from the above bacterium and identified through several spectral analyses with UV and mass spectrophotometries, and various NMR. The compound was determined to be a macrocyclic dilactone antibiotic, IKD-8344 (molecular weight: 844, molecular formula: C48H76O12). The compound selectively inhibited the growth of mycelial form of C. albicans with an MIC of 6.25 μg/ml. It also exhibited strong inhibitory effect preferentially on the mycelial form of various Candida spp. including C. krusei, C. tropicalis, and C. lusitaniae, with MICs ranging from 1.56 to 25 μg/ml. Furthermore, the compound showed no significant toxicity against SPF ICR mice up to 60 mg/kg. These results suggest that IKD-8344 is a useful lead compound for the development of novel antifungal agents, based on the preferential growth inhibition against Candida spp.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleCompound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792-
dc.title.alternativeCompound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number4-
dc.citation.endPage912-
dc.citation.startPage909-
dc.citation.volume15-
dc.contributor.affiliatedAuthorBong Sik Yun-
dc.contributor.affiliatedAuthorJae Sun Moon-
dc.contributor.affiliatedAuthorYoung Kook Kim-
dc.contributor.affiliatedAuthorSung Uk Kim-
dc.contributor.alternativeName황의일-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName여원형-
dc.contributor.alternativeName이상한-
dc.contributor.alternativeName문제선-
dc.contributor.alternativeName김영국-
dc.contributor.alternativeName임세진-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 15, no. 4, pp. 909-912-
dc.subject.keywordcandida albicans-
dc.subject.keyworddimorphism-
dc.subject.keywordIKD-8344-
dc.subject.keywordmorphological change-
dc.subject.keywordselectivity-
dc.subject.keywordvirulence-
dc.subject.localCandida albicans-
dc.subject.localcandida albicans-
dc.subject.localdimorphism-
dc.subject.localDimorphism-
dc.subject.localIKD-8344-
dc.subject.localmorphological change-
dc.subject.localselectivity-
dc.subject.localSelectivity-
dc.subject.localvirulence-
dc.subject.localVirulence-
dc.description.journalClassY-
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Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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