Journal of Microbiology and Biotechnology, vol. 15, no. 4, pp. 891-894
In the course of screening a melanin biosynthesis inhibitor, terrein, 4,5-dihydroxy-3-propenyl-2-cyclopenten-1-one, was isolated from Penicillium sp. Terrein was found to have a strong inhibitory activity on melanin formation in B16 melanoma and melanocyte Mel-Ab cells.