Large-scale fermentation for the production of teicoplanin from a mutant of Actinoplanes teichomyceticus

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Title
Large-scale fermentation for the production of teicoplanin from a mutant of Actinoplanes teichomyceticus
Author(s)
Jae-Chan Lee; Jung Won Min; Dong Jin parkKwang Hee Son; K H Yoon; H R Park; Y S Park; M G Kwon; J M Lee; Chang-Jin Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 15, no. 4, pp. 787-791
Publication Year
2005
Abstract
Mutation and its pilot-scale fermentation were conducted for the production of teicoplanin from Actinoplanes teichomyceticus. The fermentation medium was optimized by replacement and Plackett-Burman experimental design. A maximum production of 1,500 mg/l teicoplanin was obtained by pilot-scale fermentation in an optimized medium containing (g/l): 30 g maltodextrin, 5 g glucose, 5 g yeast extract, 5 g soybean meal, 0.5 g MgSO4·7H2O, 0.1 g NaCl, 0.1 g CaCl2· 2H2O, and 50 g Diaion HP-20. The production of teicoplanin was improved 3-fold from the parental strain by mutation, media optimization, and fermentation, and laboratory-scale fermentation was successfully demonstrated in a pilot-scale fermenter for the industrial production of teicoplanin.
Keyword
actinoplanes teichomyceticusfermentationmutagenesismutationteicoplanin
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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