A combined approach for locating Box H/ACA snoRNAs in the human genome

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Title
A combined approach for locating Box H/ACA snoRNAs in the human genome
Author(s)
H S Eo; K S Jo; S W Lee; Chang-Bae Kim; W Kim
Bibliographic Citation
Molecules and Cells, vol. 20, no. 1, pp. 35-42
Publication Year
2005
Abstract
A novel combined method for locating box H/ACA small nucleolar RNAs (snoRNAs) is described, together with a software tool. The method adopts both a probabilistic hidden Markov model (HMM) and a minimum free energy (MFE) rule, and filters possible candidate box H/ACA snoRNAs obtained from genomic DNA sequences. With our novel method 12 known box H/ACA snoRNAs, and one strong candidate were identified in 30 nucleolar protein genomic sequences.
Keyword
hidden markov modelminimum free energyBox H/ACA snoRNA
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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