PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza = 단삼에서 분리한 diterpene abietane 화합물의 PTP1b 저해활성

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Title
PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza = 단삼에서 분리한 diterpene abietane 화합물의 PTP1b 저해활성
Author(s)
Yu Mi Han; H Oh; MinKyun Na; B S Kim; Won Keun Oh; Bo Yeon KimDae Gwin Jeong; Seong Eon Ryu; D E Sok; Jong Seog Ahn
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 28, no. 9, pp. 1795-1797
Publication Year
2005
Abstract
Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μM, 22.4±0.6 μM and 56.1±6.3 μM, respectively.
Keyword
dihydroisotanshinone Iisocryptotanshinoneisotanshinone IIAlabiataeprotein tyrosine phosphatase 1B (PTP1B) inhibitorsalvia miltiorrhiza
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.28.1795
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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