Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica = BDX-1의 관절염 치료효과

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Title
Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica = BDX-1의 관절염 치료효과
Author(s)
Sang Bae Han; Chang Woo Lee; Yeo Dae Yoon; J H Lee; Jong Soon KangKi Hoon LeeWoon Kee Yoon; Kiho Lee; Song Kyu Park; Hwan Mook Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 8, pp. 902-908
Publication Year
2005
Abstract
An oriental herbal combination (BDX-1) was isolated from Achyranthes bidentata and Atractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.
Keyword
achyranthes bidentataatractylodes japonicaBDX-1rheumatoid arthritis
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02973875
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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