Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction = 하이드록시아이소유레아의 분해효소인 트란스싸이렉틴유사 단백질들

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Title
Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction = 하이드록시아이소유레아의 분해효소인 트란스싸이렉틴유사 단백질들
Author(s)
You Ra Lee; Do Hee Lee; Chang Won Kho; Ah Young Lee; Mi Jang; S Cho; Choong Hwan Lee; Jong Suk Lee; P K Myung; Byoung Chul ParkSung Goo Park
Bibliographic Citation
FEBS Letters, vol. 579, no. 21, pp. 4769-4774
Publication Year
2005
Abstract
Purine catabolic pathway in Bacillus subtilis is consisted of more than 14 genes. Among these genes, pucL and pucM are required for uricase activity. While PucL is known to encode the uricase itself, the function of PucM is still unclear although this protein is also indispensable for uric acid decomposition. Here, we provide evidence that PucM, a transthyretin-related protein, functions to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Based on these results, we propose that transthyretin-related proteins present in diverse organisms are not functionally related to transthyretin but actually function as a hydroxyisourate hydrolase.
Keyword
hydroxyisouratePucMtransthyretin-related proteinsuric aciduricase
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2005.07.056
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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