Quantitative trait Loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model

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Title
Quantitative trait Loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model
Author(s)
E H Kim; Chul Ho Lee; Byung Hwa Hyun; J G Suh; Y S Oh; T Namikawa; A Ishikawa
Bibliographic Citation
Experimental Animals, vol. 54, no. 4, pp. 319-325
Publication Year
2005
Abstract
In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located on chromosomes (Chrs) 8 and 10, a kidney weight QTL (Kdw1) on Chr 19, and a body weight QTL (Bdw1) on Chr 13 were detected at the genome-wide 5% or less level. The allele derived from FGS/Kist increased GSI at Gsi1, but decreased it at Gsi2. The mice homozygous for the FGS/Kist allele decreased body and kidney weights. The identified QTLs accounted for 5-8% of the phenotypic variance.
Keyword
body weightfocal glomerulosclerosiskidney weightmousequantitative trait locus
ISSN
1341-1357
Publisher
Int Press Editing Centre Inc
DOI
http://dx.doi.org/10.1538/expanim.54.319
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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