Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells = 하드록시 신남알데하이드에서 유고되는

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dc.contributor.authorS H Lee-
dc.contributor.authorC W Lee-
dc.contributor.authorJ W Lee-
dc.contributor.authorM S Choi-
dc.contributor.authorD J Son-
dc.contributor.authorY B Chung-
dc.contributor.authorC K Lee-
dc.contributor.authorK W Oh-
dc.contributor.authorD C Moon-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorJ T Hong-
dc.date.accessioned2017-04-19T09:03:20Z-
dc.date.available2017-04-19T09:03:20Z-
dc.date.issued2005-
dc.identifier.issn00062952-
dc.identifier.uri10.1016/j.bcp.2005.07.028ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7086-
dc.description.abstract2′-Hydroxycinnamaldehyde (HCA) inhibits cell growth of several human cancer cells with unknown mechanisms. We investigated the inhibitory effect of HCA on TNF-α-induced cell growth and possible signal pathway in SW620 colon cancer cells. HCA inhibited TNF-α-induced SW620 colon cell growth in time- and dose-dependent manner through induction of apoptotic cell death. Parallel with inhibitory effect on cell growth, HCA dose dependency inhibited TNF-α-induced activation of NF-κB accompanied with inhibition of the translocation of p50. HCA also induced expression of caspase-3 and Bax, but decreased Bcl-2. HCA furthermore activated ERK pathway, and ERK inhibitor reversed inhibitory effect of HCA on cell growth and transcriptional activation of NF-κB. These results demonstrate that HCA inhibits cell growth through induction of apoptotic cell death by ERK pathway-dependent NF-κB inactivation.-
dc.publisherElsevier-
dc.titleInduction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells = 하드록시 신남알데하이드에서 유고되는-
dc.title.alternativeInduction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells-
dc.typeArticle-
dc.citation.titleBiochemical Pharmacology-
dc.citation.number8-
dc.citation.endPage1157-
dc.citation.startPage1147-
dc.citation.volume70-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName이승호-
dc.contributor.alternativeName이정우-
dc.contributor.alternativeName이재웅-
dc.contributor.alternativeName최명석-
dc.contributor.alternativeName손동주-
dc.contributor.alternativeName정윤복-
dc.contributor.alternativeName이종길-
dc.contributor.alternativeName오기완-
dc.contributor.alternativeName문동철-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName홍진태-
dc.identifier.bibliographicCitationBiochemical Pharmacology, vol. 70, no. 8, pp. 1147-1157-
dc.identifier.doi10.1016/j.bcp.2005.07.028-
dc.subject.keyword2′-Hydroxycinnamaldehyde-
dc.subject.keywordApoptotic cell death-
dc.subject.keywordColon cancer-
dc.subject.keywordERK-
dc.subject.keywordNF-κB-
dc.subject.local2′-Hydroxycinnamaldehyde-
dc.subject.localApoptotic cell death-
dc.subject.localColon cancer-
dc.subject.localERK-
dc.subject.localNF-κB-
dc.subject.localNF-kB-
dc.description.journalClassY-
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Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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