Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids

Cited 389 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorChang Ji Zheng-
dc.contributor.authorJung Sung Yoo-
dc.contributor.authorT G Lee-
dc.contributor.authorH Y Cho-
dc.contributor.authorY H Kim-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T09:03:21Z-
dc.date.available2017-04-19T09:03:21Z-
dc.date.issued2005-
dc.identifier.issn00145793-
dc.identifier.uri10.1016/j.febslet.2005.08.028ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7087-
dc.description.abstractLong-chain unsaturated fatty acids, such as linoleic acid, show antibacterial activity and are the key ingredients of antimicrobial food additives and some antibacterial herbs. However, the precise mechanism for this antimicrobial activity remains unclear. We found that linoleic acid inhibited bacterial enoyl-acyl carrier protein reductase (FabI), an essential component of bacterial fatty acid synthesis, which has served as a promising target for antibacterial drugs. Additional unsaturated fatty acids including palmitoleic acid, oleic acid, linolenic acid, and arachidonic acid also exhibited the inhibition of FabI. However, neither the saturated form (stearic acid) nor the methyl ester of linoleic acid inhibited FabI. These FabI-inhibitory activities of various fatty acids and their derivatives very well correlated with the inhibition of fatty acid biosynthesis using [14C] acetate incorporation assay, and importantly, also correlated with antibacterial activity. Furthermore, the supplementation with exogenous fatty acids reversed the antibacterial effect of linoleic acid, which showing that it target fatty acid synthesis. Our data demonstrate for the first time that the antibacterial action of unsaturated fatty acids is mediated by the inhibition of fatty acid synthesis.-
dc.publisherWiley-
dc.titleFatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids-
dc.title.alternativeFatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number23-
dc.citation.endPage5162-
dc.citation.startPage5157-
dc.citation.volume579-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeName정창길-
dc.contributor.alternativeName유정성-
dc.contributor.alternativeName이태규-
dc.contributor.alternativeName조희영-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationFEBS Letters, vol. 579, no. 23, pp. 5157-5162-
dc.identifier.doi10.1016/j.febslet.2005.08.028-
dc.subject.keywordAntibacterial-
dc.subject.keywordEnoyl-acyl carrier protein reductase-
dc.subject.keywordFatty acid synthesis-
dc.subject.keywordLinoleic acid-
dc.subject.keywordUnsaturated fatty acid-
dc.subject.localAntibacterial-
dc.subject.localEnoyl-acyl carrier protein reductase-
dc.subject.localFatty acid synthesis-
dc.subject.localLinoleic acid-
dc.subject.localUnsaturated fatty acid-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.