A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Min Soo Shin | - |
| dc.contributor.author | Eun hwa Kang | - |
| dc.contributor.author | Young Ik Lee | - |
| dc.date.accessioned | 2017-04-19T09:03:21Z | - |
| dc.date.available | 2017-04-19T09:03:21Z | - |
| dc.date.issued | 2005 | - |
| dc.identifier.issn | 0166-3542 | - |
| dc.identifier.uri | 10.1016/j.antiviral.2005.06.005 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7089 | - |
| dc.description.abstract | A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C 14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50 = 0.07 μg/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals. | - |
| dc.publisher | Elsevier | - |
| dc.title | A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes | - |
| dc.title.alternative | A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes | - |
| dc.type | Article | - |
| dc.citation.title | Antiviral Research | - |
| dc.citation.number | 3 | - |
| dc.citation.endPage | 168 | - |
| dc.citation.startPage | 163 | - |
| dc.citation.volume | 67 | - |
| dc.contributor.affiliatedAuthor | Min Soo Shin | - |
| dc.contributor.affiliatedAuthor | Eun hwa Kang | - |
| dc.contributor.affiliatedAuthor | Young Ik Lee | - |
| dc.contributor.alternativeName | 신민수 | - |
| dc.contributor.alternativeName | 강은화 | - |
| dc.contributor.alternativeName | 이영익 | - |
| dc.identifier.bibliographicCitation | Antiviral Research, vol. 67, no. 3, pp. 163-168 | - |
| dc.identifier.doi | 10.1016/j.antiviral.2005.06.005 | - |
| dc.subject.keyword | HBeAg secretion | - |
| dc.subject.keyword | Hepatitis B virus-e antigen | - |
| dc.subject.keyword | NMR spectrometer | - |
| dc.subject.keyword | Phyllanthus urinaria | - |
| dc.subject.local | HBeAg secretion | - |
| dc.subject.local | Hepatitis B virus-e antigen | - |
| dc.subject.local | hepatitis B virus-e antigen | - |
| dc.subject.local | NMR spectrometer | - |
| dc.subject.local | Phyllanthus urinaria | - |
| dc.description.journalClass | Y | - |
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