Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells

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Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells
H N Nguyen; D Y Hwang; Y K Kim; Do Young Yoon; Jae Wha Kim; M S Lee; M K Lee; Y P Yun; K W Oh; J T Hong
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 9, pp. 1073-1078
Publication Year
A presenilin 2 mutation is believed to be involved in the development of Alzheimer's disease. In addition, transgenic mice with a presenilin 2 mutation have been reported to have learning and memory impairments. In this study, exposing PC12 cells expressing mutant presenilin 2 to 50 μM Aβ25-35, 30 mM L-glutamate and 50 μM H2O 2 caused a significant increase in acetylcholine esterase activity. An in vivo study revealed high levels of this enzyme activity in the mutant presenilin 2 transgenic brains compared with the wild type presenilin 2 transgenic and non-transgenic samples. These results suggest that a mutant presenilin 2-induced neurodegeneration in Alzheimer's disease might be involved in the increase in acetylcholinesterase activity. These findings might help in the development of an appropriate therapeutic intervention targeting mutant presenilin 2-induced Alzheimer's disease.
acetylcholine esterasealzheimer's diseaseneuronal cellpresenilin 2
Pharmaceutical Soc Korea
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Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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