Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis = Hovenia dulcis로부터 분리한 phenolic compounds의 neuroprotective와 free radical scavenging activities

Cited 60 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorGao Li-
dc.contributor.authorB S Min-
dc.contributor.authorC Zheng-
dc.contributor.authorJoongku Lee-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T09:03:26Z-
dc.date.available2017-04-19T09:03:26Z-
dc.date.issued2005-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/BF02977346ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7112-
dc.description.abstractThe EtOAc-soluble fraction from a methanolic extract of Hovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1-8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin (6), 2,3,4-trihydrobenzoic acid (7), and (+)-afzelechin (8). Among these, compounds 6 and 8 had a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. Furthermore, compound 6 had a DPPH free radical scavenging effect with an IC50 value of 57.7 μM, and a superoxide anion radical scavenging effect with an IC50 value of 8.0 μM. Both compounds 6 and 8 had ABTS cation radical scavenging effects with IC50 values of 7.8 μM and 23.7 μM, respectively. These results suggest that compounds 6 and 8 could be neuroprotectants owing to their free radical scavenging activities.-
dc.publisherPharmaceutical Soc Korea-
dc.titleNeuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis = Hovenia dulcis로부터 분리한 phenolic compounds의 neuroprotective와 free radical scavenging activities-
dc.title.alternativeNeuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number7-
dc.citation.endPage809-
dc.citation.startPage804-
dc.citation.volume28-
dc.contributor.affiliatedAuthorJoongku Lee-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName이호-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeNameZheng-
dc.contributor.alternativeName이중구-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 28, no. 7, pp. 804-809-
dc.identifier.doi10.1007/BF02977346-
dc.subject.keyword(+)-Afzelechin-
dc.subject.keyword(-)-Catechin-
dc.subject.keywordABTS-
dc.subject.keywordDPPH-
dc.subject.keywordHovenia dulcis-
dc.subject.keywordHT22 Cells-
dc.subject.keywordNeuroprotection-
dc.subject.keywordSuperoxide-
dc.subject.local(+)-Afzelechin-
dc.subject.local(-)-Catechin-
dc.subject.localABTS-
dc.subject.localDPPH-
dc.subject.localHovenia dulcis-
dc.subject.localHT22 cells-
dc.subject.localHT22 Cells-
dc.subject.localNeuroprotection-
dc.subject.localneuroprotection-
dc.subject.localSuperoxide-
dc.subject.localsuperoxide-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.