Antitumour activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida

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Title
Antitumour activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida
Author(s)
W P Jones; T Lobo-Echeverri; Q Mi; H Chai; Dongho Lee; D D Soejarto; G A Cordell; J M Pezzuto; S M Swanson; A D Kinghorn
Bibliographic Citation
Journal of Pharmacy and Pharmacology, vol. 57, no. 9, pp. 1101-1108
Publication Year
2005
Abstract
As part of an ongoing collaborative effort to discover pew anticancer agents from plants, an extract obtained from the leaves and twigs of Avicennia germinans, collected in a coastal area of southern Florida, was identified as possessing cytotoxic activity in a panel of human cancer cell lines. Fractionation of the petroleum ether partition, using cytotoxicity to guide the fractionation, led to the isolation of 3-chlorodeoxylapachol. The antitumour potential of 3-chlorodeoxylapachol was demonstrated with the in-vivo hollow fibre assay, a model of antitumour activity using human cancer cell-filled fibres implanted into mice. The possibility that this compound is an artefact of the isolation procedure was ruled out by liquid chromatography-mass spectrometry analysis of extracts prepared without the use of chlorinated solvent. In conclusion, 3-chlordeoxylapachol, a secondary metabolite obtained from the chloroform-soluble extract of a mangrove tree, was cytotoxic in a panel of human cancer cells, and active against KB human cancer cells in the murine hollow fibre antitumour model, with selectivity in KB cells for the intravenous site at lower doses, indicating possible metabolic activation.
ISSN
0022-3573
Publisher
Wiley
DOI
http://dx.doi.org/10.1211/jpp.57.9.0005
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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