A practical enzymatic synthesis of UDP sugars and NDP glucoses

Cited 23 time in scopus
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Title
A practical enzymatic synthesis of UDP sugars and NDP glucoses
Author(s)
JungDon Bae; Kwang Ho Kim; DooIl Kim; Yongseok Choi; Joong Su Kim; Sukhoon Koh; S I Hong; Dae Sil Lee
Bibliographic Citation
Chembiochem, vol. 6, no. 11, pp. 1963-1966
Publication Year
2005
Abstract
Mix and match. Nucleotide sugars are essential as glycoside donors to glycosyltransferases for the synthesis of bioactive metabolites. With 45 combinations of reactions with five NTPs and nine sugar-1-phosphates (Su1Ps) by recombinant UDP-sugar pyrophosphorylase (Up) from Thermus caldophilus GK24, the enzyme showed broad substrate specificity toward five types of NTP with glucose-1-phosphate as well as four Su1Ps with UTP, affording all nine nucleotide sugars.
Keyword
Enzyme catalysisGlycosyltransferasesNucleotide sugarsThermus caldophilus
ISSN
1439-4227
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/cbic.200500183
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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