Effective prevention of lethal acute graft-versus-host disease by combined immunosuppressive therapy with prodigiosin and cyclosporine A = 프로디지오신의 GVHD 치료효과

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Title
Effective prevention of lethal acute graft-versus-host disease by combined immunosuppressive therapy with prodigiosin and cyclosporine A = 프로디지오신의 GVHD 치료효과
Author(s)
Sang Bae Han; Chang Woo Lee; Yeo Dae Yoon; Jong Soon KangKi Hoon LeeWoon Kee Yoon; Young Kook Kim; Kiho Lee; Song Kyu Park; Hwan Mook Kim
Bibliographic Citation
Biochemical Pharmacology, vol. 70, no. 10, pp. 1518-1526
Publication Year
2005
Abstract
Prodigiosin (PDG), a bacterial metabolite, is a known T cell-specific immunosuppressant. Here, we compared its inhibitory potency and mode of action with cyclosporine A (CsA) in a mouse model. PDG efficiently inhibited T cell proliferation with an IC50 of 3.37 ng/ml, a similar dose to that of CsA (IC50 of 2.71 ng/ml). PDG inhibited only IL-2Rα expression, but not IL-2 expression, whereas CsA inhibited both. Exogenously added IL-2 reversed the suppressive activity of CsA, but not that of PDG. Moreover, although both PDG and CsA markedly reduced mortality rates in lethal acute graft-versus-host disease (GVHD), the combined treatment was more effective than either drug alone. These results demonstrate that PDG and CsA have similar inhibitory potencies, but different modes of action, and suggest that PDG has potential use as a supplementary immunosuppressant in combination with CsA for the treatment of GVHD.
Keyword
Cyclosporin AGraft-versus-host diseaseProdigiosin
ISSN
0006-2952
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bcp.2005.08.017
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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