Annexin A3 is a potential angiogenic mediator = Annexin A3의 혈관신생 촉진효과

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Annexin A3 is a potential angiogenic mediator = Annexin A3의 혈관신생 촉진효과
Jae Eun Park; Do Hee Lee; Jung A Lee; Sung Goo ParkNam-Soon KimByoung Chul Park; S Cho
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 337, no. 4, pp. 1283-1287
Publication Year
Angiogenesis is a complex process that is regulated by a variety of angiogenic activators and inhibitors. Disruption of the balanced angiogenesis leads to the progress of diseases such as tumor growth, rheumatoid arthritis, and various blood vessel-related disorders. Even though a number of proteins involved in angiogenesis have been identified so far, more protein factors remain to be identified due to complexity of the process. Here we report that annexin A3 (ANXA3) induces migration and tube formation of human umbilical vein endothelial cells. High level of vascular endothelial growth factor (VEGF), a prominent angiogenic factor, is also detected in conditioned medium obtained from cells transfected with ANXA3 expression plasmid. Reporter assays show that ANXA3 enhances hypoxia-inducible factor-1 (HIF-1) transactivation activity. Taken together, our results suggest that ANXA3 is a novel angiogenic factor that induces VEGF production through the HIF-1 pathway.
AngiogenesisAnnexin A3Hypoxia-inducible factor-1Vascular endothelial growth factor
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Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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