Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation

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Title
Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation
Author(s)
S M Lee; J W Lee; Y S Song; D Y Hwang; Y K Kim; S Y Nam; D J Kim; Y W Yun; Do Young Yoon; J T Hong
Bibliographic Citation
Journal of Neuroscience Research, vol. 82, no. 4, pp. 542-550
Publication Year
2005
Abstract
Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with elevated ryanodine-receptor (RyR) expression and intracellular calcium levels. Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but caffeine, an activator of RyR, exacerbated PS2 mutation-induced interference with cell differentiation. Our results indicate that mutant PS2 inhibits normal neuronal cell differentiation and that RyR-mediated calcium overrelease may be a significant factor.
Keyword
calciumcell differentiationpresenilin 2ryanodine receptor
ISSN
0360-4012
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/jnr.20655
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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