Signaling pathways implicated in α-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes

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dc.contributor.authorKyung Joo Cho-
dc.contributor.authorJung Hyun Shim-
dc.contributor.authorMin Chul Cho-
dc.contributor.authorYong Kyung Choe-
dc.contributor.authorJ T Hong-
dc.contributor.authorD C Moon-
dc.contributor.authorJ W Kim-
dc.contributor.authorDo Young Yoon-
dc.date.accessioned2017-04-19T09:03:33Z-
dc.date.available2017-04-19T09:03:33Z-
dc.date.issued2005-
dc.identifier.issn07302312-
dc.identifier.uri10.1002/jcb.20561ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7141-
dc.description.abstractMelanocortins, besides their central roles, have also recently been reported to regulate adipocyte metabolism. In this study, we attempted to characterize the mechanism underlying α-melanocyte-stimulating hormone (MSH)-induced lipolysis, and compared it with that of the adrenocorticotrophin hormone (ACTH) in 3T3-L1 adipocytes. Similar to ACTH, MSH treatment resulted in the release of glycerol into the cell supernatant. The activity of hormone-sensitive lipase, a rate-limiting enzyme, which is involved in lipolysis, was significantly increased by MSH treatment. In addition, a variety of kinases, including protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) were also phosphorylated as the result of MSH treatment, and their specific inhibitors caused a reduction in MSH-induced glycerol release and HSL activity, indicating that MSH-induced lipolysis was mediated by these kinases. These results suggest that PKA and ERK constitute the principal signaling pathways implicated in the MSH-induced lipolytic process via the regulation of HSL in 3T3-L1 adipocytes.-
dc.publisherWiley-
dc.titleSignaling pathways implicated in α-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes-
dc.title.alternativeSignaling pathways implicated in alpha-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes-
dc.typeArticle-
dc.citation.titleJournal of Cellular Biochemistry-
dc.citation.number4-
dc.citation.endPage878-
dc.citation.startPage869-
dc.citation.volume96-
dc.contributor.alternativeName조경주-
dc.contributor.alternativeName심정현-
dc.contributor.alternativeName조민철-
dc.contributor.alternativeName최용경-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName문동철-
dc.contributor.alternativeName김종완-
dc.contributor.alternativeName윤도영-
dc.identifier.bibliographicCitationJournal of Cellular Biochemistry, vol. 96, no. 4, pp. 869-878-
dc.identifier.doi10.1002/jcb.20561-
dc.subject.keywordACTH-
dc.subject.keywordadipocyte-
dc.subject.keywordhormone-sensitive lipase-
dc.subject.keywordlipolysis-
dc.subject.keywordmelanocortins-
dc.subject.keywordMSH-
dc.subject.localACTH-
dc.subject.localadipocyte-
dc.subject.localAdipocyte-
dc.subject.localhormone-sensitive lipase-
dc.subject.localHormone-sensitive lipase-
dc.subject.locallipolysis-
dc.subject.localmelanocortins-
dc.subject.localMSH-
dc.description.journalClassY-
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