DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kyung Joo Cho | - |
dc.contributor.author | Jung Hyun Shim | - |
dc.contributor.author | Min Chul Cho | - |
dc.contributor.author | Yong Kyung Choe | - |
dc.contributor.author | J T Hong | - |
dc.contributor.author | D C Moon | - |
dc.contributor.author | J W Kim | - |
dc.contributor.author | Do Young Yoon | - |
dc.date.accessioned | 2017-04-19T09:03:33Z | - |
dc.date.available | 2017-04-19T09:03:33Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.uri | 10.1002/jcb.20561 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7141 | - |
dc.description.abstract | Melanocortins, besides their central roles, have also recently been reported to regulate adipocyte metabolism. In this study, we attempted to characterize the mechanism underlying α-melanocyte-stimulating hormone (MSH)-induced lipolysis, and compared it with that of the adrenocorticotrophin hormone (ACTH) in 3T3-L1 adipocytes. Similar to ACTH, MSH treatment resulted in the release of glycerol into the cell supernatant. The activity of hormone-sensitive lipase, a rate-limiting enzyme, which is involved in lipolysis, was significantly increased by MSH treatment. In addition, a variety of kinases, including protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) were also phosphorylated as the result of MSH treatment, and their specific inhibitors caused a reduction in MSH-induced glycerol release and HSL activity, indicating that MSH-induced lipolysis was mediated by these kinases. These results suggest that PKA and ERK constitute the principal signaling pathways implicated in the MSH-induced lipolytic process via the regulation of HSL in 3T3-L1 adipocytes. | - |
dc.publisher | Wiley | - |
dc.title | Signaling pathways implicated in α-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes | - |
dc.title.alternative | Signaling pathways implicated in alpha-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.citation.title | Journal of Cellular Biochemistry | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 878 | - |
dc.citation.startPage | 869 | - |
dc.citation.volume | 96 | - |
dc.contributor.affiliatedAuthor | Kyung Joo Cho | - |
dc.contributor.affiliatedAuthor | Jung Hyun Shim | - |
dc.contributor.affiliatedAuthor | Min Chul Cho | - |
dc.contributor.affiliatedAuthor | Yong Kyung Choe | - |
dc.contributor.affiliatedAuthor | Do Young Yoon | - |
dc.contributor.alternativeName | 조경주 | - |
dc.contributor.alternativeName | 심정현 | - |
dc.contributor.alternativeName | 조민철 | - |
dc.contributor.alternativeName | 최용경 | - |
dc.contributor.alternativeName | 홍진태 | - |
dc.contributor.alternativeName | 문동철 | - |
dc.contributor.alternativeName | 김종완 | - |
dc.contributor.alternativeName | 윤도영 | - |
dc.identifier.bibliographicCitation | Journal of Cellular Biochemistry, vol. 96, no. 4, pp. 869-878 | - |
dc.identifier.doi | 10.1002/jcb.20561 | - |
dc.subject.keyword | ACTH | - |
dc.subject.keyword | adipocyte | - |
dc.subject.keyword | hormone-sensitive lipase | - |
dc.subject.keyword | lipolysis | - |
dc.subject.keyword | melanocortins | - |
dc.subject.keyword | MSH | - |
dc.subject.local | ACTH | - |
dc.subject.local | Adipocyte | - |
dc.subject.local | adipocyte | - |
dc.subject.local | Adipocytes | - |
dc.subject.local | adipocytes | - |
dc.subject.local | Hormone Sensitive Lipase | - |
dc.subject.local | hormone-sensitive lipase | - |
dc.subject.local | Hormone-sensitive lipase | - |
dc.subject.local | lipolysis | - |
dc.subject.local | melanocortins | - |
dc.subject.local | MSH | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.