Stage-dependent gene expression profiles during natural killer cell development

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Title
Stage-dependent gene expression profiles during natural killer cell development
Author(s)
H S Kang; E M Kim; S Lee; Suk Ran Yoon; T Kawamura; Young Cheol Lee; S Kim; P K Myung; S M Wang; In Pyo Choi
Bibliographic Citation
Genomics, vol. 86, no. 5, pp. 551-565
Publication Year
2005
Abstract
Natural killer (NK) cells develop from hematopoietic stem cells (HSCs) in the bone marrow. To understand the molecular regulation of NK cell development, serial analysis of gene expression (SAGE) was applied to HSCs, NK precursor (pNK) cells, and mature NK cells (mNK) cultured without or with OP9 stromal cells. From 170,464 total individual tags from four SAGE libraries, 35,385 unique genes were identified. A set of genes was expressed in a stage-specific manner: 15 genes in HSCs, 30 genes in pNK cells, and 27 genes in mNK cells. Among them, lipoprotein lipase induced NK cell maturation and cytotoxic activity. Identification of genome-wide profiles of gene expression in different stages of NK cell development affords us a fundamental basis for defining the molecular network during NK cell development.
Keyword
developmentLPLNK cellsSAGE
ISSN
0888-7543
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ygeno.2005.06.010
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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